Spravato® (esketamine) is an FDA-approved nasal spray for treatment-resistant depression — depression that hasn't improved after two or more antidepressants. We offer it at all three of our clinics, with a calm private room and a care team by your side.
Prefer not to use insurance? Our out-of-network rate is $99 per session, plus the medication — most patients qualify for manufacturer savings.
The single-use nasal spray, taken in our clinic under
medical supervision.
Spravato® is the brand name for esketamine, FDA-approved in 2019 for treatment-resistant depression and accute suicidal thoughts. You take it as a nasal spray in our office, with a care team beside you the whole time. It can work alongside the daily antidepressant you already take — or, as of 2025, on its own.
Most antidepressants target serotonin and can take several weeks to show an effect. Spravato works on glutamate, the brain's most abundant chemical messenger — a different pathway entirely. It's thought to help nerve cells form new connections, a process called neuroplasticity. Some people notice a shift within days rather than weeks.
Works on glutamate rather than serotonin — a different pathway than the antidepressants you've already tried.
Thought to help nerve cells form new connections, a process called neuroplasticity.
Some people notice a shift within days, not the weeks most antidepressants take.
If pills alone haven't worked, you're not out of options. Spravato takes a different road — and it can travel alongside the medication you're already on.
Spravato is one of the most studied new options for hard-to-treat depression, with large trials behind its 2019 FDA approval. Here's what they found.
Two things stand out in the data: Spravato can work quickly, and staying with treatment after you feel better is what keeps you well. That is why we plan a full series with you rather than a one-time visit.
You settle into a private room, give yourself a few sprays, and rest while our team stays close for about two hours. Many people feel dreamy or a little detached for a while — that's expected, and it fades before you leave. You'll need a ride home, and shouldn't drive until the next day. Most people start with two visits a week for four weeks, then one a week for four weeks.
Most patients use insurance and pay very little to start. Here's exactly how it works.
We're in-network with Regence and Cigna, and Spravato itself is covered by most medical plans — many patients pay as little as $10 per session
We take care of the prior authorization and pharmacy coordination, so most patients start in days, not months (insurance pre-auth timeline can vary)
Prefer not to use insurance, or between plans? Spravato out-of-network is $99 per session plus the medication — most patients qualify for manufacturer savings that cover it.
Costs can vary by plan. Our team will walk you through your exact out-of-pocket cost before you start, with no obligation.
We handle the paperwork and the pharmacy, so most patients start in days, not months.
A relaxed talk about your symptoms and insurance. No commitment.
Meet our nurse practitioner to confirm Spravato is right for you.
We handle the paperwork. Most answers arrive in 3 to 5 days.
We send your prescription to a trusted specialty pharmacy.
Your medication arrives at our clinic, ready for your first appointment.
Start with two visits weekly, then transition to once weekly.
We offer Spravato at all three clinics. You can move between them if it is easier for your schedule.
Learn more about the care teams serving patients at each of our three clinics.
Care here is rarely one tool. These work well alongside Spravato for many patients.
Book a free consult at our Bellevue, Seattle, or Tacoma clinic. We will answer your questions and walk you through cost and insurance, with no pressure.
We're a preferred provider with CareCredit and offer interest-deferred payment plans, so you can begin care now and spread the cost over time. Apply or see if you prequalify in just a few minutes.
Apply with CareCredit